YES!! The first season of Clarissa Explains it All is coming out on DVD May 17th!!! There's an article about it here. I was just talking about this a couple nights ago, how I really wanted them to make a DVD of that show. Apparently, they're gonna come out with DVD's of Pete and Pete too, which is my other favorite old Nickelodeon show, along with Salute Your Shorts and Are You Afraid of the Dark (I'm not as excited about those).
My only fear is that the shows won't be nearly as funny as I remember, which I'm pretty sure they won't. But hey. . . if nothing else, they'll still bring back all the childhood memories, right?